Depends on the features of the position, but in general yes.
- you want there to be a high amount of complexity
- you often want it to be uncommon
- you want some compensation for whatever makes it unsound, often tempo but maybe something else
- sometimes it's a position where the opponent has to play a long precise string of engine moves to prove it unsound and so in practice it just isn't a concern
What I think players shouldn't do, though, is cultivate an impulse to just ignore the engine / ignore chess principles as if they mean nothing. Rules have exceptions, but you don't want to ignore them all the time.
Is it possible that if you know opening well enough even if its bad or unsound you can still get a decent winrate with it.